Shanghai Biopharmaleader co.,ltd

Date: 18th July 2016
Monomethylauristatin E CAS:474645-27-7
If you are going to consult the information about 474645-27-7 from one of the leading 474645-27-7 manufacturers and suppliers in China, Biopharmaleader Co.,Ltd is always at your service.Product InformationCAS NO.474645-27-7?Product NameMonomethylauristatin ESynonymsMMAEFormulaC39H67N5O7Molecular Weight717.98Spec / Purity98%minSupply CapacityDetailsMonomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.
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