Shanghai Biopharmaleader co.,ltd

Date: 18th July 2016
Ribociclib CAS:1211441-98-3
If you are going to consult the information about 1211441-98-3 from one of the leading 1211441-98-3 manufacturers and suppliers in China, Biopharmaleader Co.,Ltd is always at your service.Product InformationCAS NO.1211441-98-3?Product NameRibociclibSynonymsLEE011FormulaC23H30N8OMolecular Weight434.54Spec / Purity98%minSupply CapacityDetailsRibociclib (LEE011) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. It specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
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