Shanghai Biopharmaleader co.,ltd

Date: 18th July 2016
Ribociclib CAS:1211441-98-3
If you are going to consult the information about 1211441-98-3 from one of the leading 1211441-98-3 manufacturers and suppliers in China, Biopharmaleader Co.,Ltd is always at your service.Product InformationCAS NO.1211441-98-3?Product NameRibociclibSynonymsLEE011FormulaC23H30N8OMolecular Weight434.54Spec / Purity98%minSupply CapacityDetailsRibociclib (LEE011) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. It specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
Latest News
Contact Information



Building 11, NO. 3802 ShenGang Rd, Xinfei Corporation Home, SongJiang District, Shanghai,201611, China.
Shanghai, 201611


Contact Form